Document Type

Article

Article Version

Publisher's PDF

Publication Date

1994

Abstract

Increased intracellular incorporation of [3H]corticosterone in Candida albicans was dependent on cell surface hydrophobicity. C. albicans strains were grown in culture conditions that induced surface hydrophobicity, and cell wall conditions were evaluated with a polystyrene microsphere assay. Germ tubes, which exhibited the greatest cell surface hydrophobicity, incorporated seven times more radiolabel than the hydrophilic yeast forms. Hydrophobic yeasts contained four times more [3H]corticosterone than their polar counterparts. Hydrophobic yeasts incubated for 48 h on nutrient agar containing corticosterone showed reduced colony size compared with controls. These results demonstrate that environmental factors which augment cell wall hydrophobicity in C. albicans can increase the incorporation of corticosterone, which may influence the metabolic activities in this organism.

Comments

Copyright 1994 American Society for Microbiology

The final publisher PDF has been archived here with permission from the copyright holder.

Publication Title

Infection and immunity

Published Citation

Braun, P. C. (1994). Surface hydrophobicity enhances corticosterone incorporation in Candida albicans. Infection and immunity, 62(9), 4087-4090.

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